Gabapentin Medication and Its Mechanism of Action

Table of Contents

Indications and Mechanism of Action

Gabapentin is a generic name of neurontin, a medication in the form of capsules and tablets which are used as a part of adjunctive therapy for patients with partial onset seizures. With the help of the chosen drug, adult patients, as well as patients older than 3 years, may control seizures of different types and avoid epilepsy in case it is regularly taken. Another important indication of gabapentin is to manage postherpetic neuralgia (Markley, Dunteman, Kareht, & Sweeney, 2015). This condition is characterized by pain persistence for more than three months and associated with sleep disturbance and low back pain. Gabapentin is also used orally to relieve painful restless leg syndrome and decrease the possibility of complications because of amyotrophic lateral sclerosis (Carrasco, Rao, Bearer, & Sundarrajan, 2015; Chiò, Mora, & Lauria, 2017). Tremors and nystagmus are the health problems that may be solved or, at least, controlled by taking gabapentin 3 times daily.

The mechanism of action of gabapentin is based on analgesic and antiepileptic qualities of the drug. However, not many current studies can be found on this topic. Fornasari (2017) compares the mechanisms of action of gabapentin and pregabalin, focusing on alpha-2/delta-1 expression. Though the chosen drug has no direct connection to the work of the neurotransmitter y-aminobutyric acid known as GABA, it has a property to strengthen the qualities of GABA. In addition, gabapentin is able to inhibit calcium channels by opening ionizing channels. Finally, the recent discovery proves the possibility of gabapentin to determine the work of certain voltage-dependent calcium channels as the main inhibitor of the alpha-2/delta-1 subunit (Offord & Isom, 2016). Still, it is recommended to continue researching gabapentin mechanism of action and its role in GABA synthesis.

Precautions and Contraindications

Special attention is paid to the section of precautions and contradictions of gabapentin due to associated depression and possible suicidal thoughts. First of all, it is recommended to check the level of sensitivity to this drug and avoid using gabapentin in patients who demonstrate hypersensitivity to any of its components. Then, the analysis of the emotional well-being cannot be neglected as it is a chance to understand what kind of reactions may be observed and what interventions should be offered. Anticonvulsants like gabapentin can promote the emergence of depression, as well as the thoughts about self-harm and suicide. Unusual changes in mood and behavior have to be reported.

Another significant precaution touches upon the patients who have renal problems or are on dialysis. This drug can considerably reduce renal function and develop serious renal impairment. Finally, it is recommended for pregnant women to avoid taking gabapentin because of the year limitations that exclude neonates (Markley et al., 2015). Still, other authors support the idea of using gabapentin to avoid the complications of restless leg syndrome among pregnant women (Carrasco et al., 2015). This contradiction is a serious background to continue investigating the characteristics of gabapentin.

Adverse Reactions

Even one dose of gabapentin can cause a number of side effects and change the health conditions of a patient. Among the most frequent adverse reactions, it is possible to identify the following: diarrhea, dizziness, dry mouth, drowsiness, and the loss of coordination. Some patients may report that they start observing unpredictable tremor or eye movement. Abuse and addiction are the outcomes that hard to be predicted because much depends on the patient’s history. All these reactions and outcomes have to be discussed with a doctor. Sleepiness is a side effect that prevents drivers from taking this drug unless they are hospitalized or stay at home for a while. Finally, as it has already been mentioned, gabapentin may increase suicidal thoughts and behaviors. Therefore, depression and behavioral changes should be defined as the possible human reactions to this drug. Another adverse reaction like the development of adenocarcinoma (or cancer) cells is not approved by human studies but remains a serious research topic in the studies with rats.

Patient Education

Patient education plays an important role in taking drugs and avoiding serious complications. It is not enough to inform a patient about the required doses and schedules. However, one should admit that overdosing is a problem some patients still face. As soon as adverse reactions are observed, or the patient suffers from breathing troubles and unpredictable changes, people should call 911 or address to the nearest hospital. It is also necessary to discuss the worth of gabapentin and evaluate the expectations that have to be achieved. Patients have to be prepared for such conditions as depression, suicidal thoughts, and mood changes. If possible, family members or caregivers should observe the patient during the first day of taking the drug.

Education must include the explanation the possible outcomes of interactions between gabapentin and opioids, including the changes in the work of the central nervous system. Gabapentin may cause dependence, and patients have to learn how to control their treatment and avoid abuse complications. Communication with a psychologist is one of the possible solutions. To conclude, a number of treating properties of gabapentin cover its possible negative sides and adverse reactions making this drug one of the best treatment options for patients with seizures and postherpetic neuralgia.


Carrasco, M., Rao, S. C., Bearer, C. F., & Sundararajan, S. (2015). Neonatal gabapentin withdrawal syndrome. Pediatric Neurology, 53(5), 445-447. Web.

Chiò, A., Mora, G., & Lauria, G. (2017). Pain in amyotrophic lateral sclerosis. The Lancet Neurology, 16(2), 144-157. Web.

Markley, H. G., Dunteman, E. D., Kareht, S., & Sweeney, M. (2015). Real-world experience with once-daily gabapentin for the treatment of postherpetic neuralgia (PHN). The Clinical Journal of Pain, 31(1), 58-65. Web.

Offord, J., & Isom, L. L. (2016). Drugging the undruggable: Gabapentin, pregabalin and the calcium channel α2δ subunit. Critical Reviews in Biochemistry and Molecular Biology, 51(4), 246-256. Web.

Calculate the price
Make an order in advance and get the best price
Pages (550 words)
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
How it works
Receive a 100% original paper that will pass Turnitin from a top essay writing service
step 1
Upload your instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
Pro service tips
How to get the most out of your experience with Online Academic Experts
One writer throughout the entire course
If you like the writer, you can hire them again. Just copy & paste their ID on the order form ("Preferred Writer's ID" field). This way, your vocabulary will be uniform, and the writer will be aware of your needs.
The same paper from different writers
You can order essay or any other work from two different writers to choose the best one or give another version to a friend. This can be done through the add-on "Same paper from another writer."
Copy of sources used by the writer
Our college essay writers work with ScienceDirect and other databases. They can send you articles or materials used in PDF or through screenshots. Just tick the "Copy of sources" field on the order form.
See why 20k+ students have chosen us as their sole writing assistance provider
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
Emergency Management
Overall, I think it's a great service. I have yet to submit the assignment, so I don't know what kind of grade I'll get. But customer service was excellent. Reviews were made and the assignment proofed for satisfaction.
Customer 453015, December 15th, 2021
Thank you!
Customer 453145, April 19th, 2022
Classic English Literature
It was my first time using such a service. Essay was good and nicely formatted.
Customer 452441, February 16th, 2022
Looks amazing!
Customer 453283, September 2nd, 2022
Emergency Management
Customer 453015, October 28th, 2022
IT, Web
Awesome paper in such a short amount of time. Was in a jam with another service who didn't deliver, but Theresa did the job correctly. I will use her again to do my essays for sure!
Customer 452967, November 27th, 2021
Human Resources Management (HRM)
On time and as always a great service! This semester has been very time consuming a tough for my family so this service has not only been a life saver but helped me keep up my grades! If you are in a time crunch or need help, don't hesitate! They are worth it!
Customer 453077, April 4th, 2022
Criminal Justice
The paper was not accused of plagiarism and was written very well. I will let you know the grade once it is graded. Thank you
Customer 452671, April 26th, 2021
Thank you!!! I received my order in record timing.
Customer 452551, February 9th, 2021
Business and administrative studies
Excellent work and done hen needed and they always get it done ahead of time
Customer 453201, October 17th, 2022
Business and administrative studies
excellent work
Customer 453201, November 2nd, 2022
Business and administrative studies
Customer 453201, October 22nd, 2022
Customer reviews in total
Current satisfaction rate
3 pages
Average paper length
Customers referred by a friend
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat
Live ChatWhatsApp