Chemotherapy-Induced Nausea and Vomiting Treatment

Problem Statement

Cancer has become the most dreaded condition and the most common cause of death over the past few years (National Cancer Institute, 2016). Gastric cancer, as one of the specimens of the disease, has been affecting the U.S. population significantly, even though the rates of disease development have dropped recently. Nowadays, gastric cancer affects 7.3 people per 100,000 cases (National Cancer Institute, 2014). Even though chemotherapy (FOLFOX) has been used quite successfully to address gastric cancer, chemotherapy-induced nausea and vomiting (CINV), which is the side effect thereof, poses a significant threat to the success of the patient’s recovery (National Cancer Institute, 2014). Therefore, there is a need to design the framework for addressing the issue of CINV in cancer patients undergoing FOLFOX treatment. Particularly, the use of pharmacological treatment (i.e., antiemetics with high binding affinities, such as Palonosetron and Olanzapine (Janelsins et al., 2013)) should be compared to the alternative options (i.e., Chinese herbal medications such as Shenqi fuzheng (Sheikhi, Ebadi, Talaeizadeh, & Rahmani, 2015; Jiang et al., 2015)).

Research Purpose

The goal of the study is to compare the effects of the traditional treatment of CINV in gastric cancer patients (i.e., the application of pharmacological methods) and the usage of the alternative approaches (particularly, herbal medicine) so that possible means of reducing CINV as a severe side effect could be found. The research will focus on identifying the advantage and disadvantages of each approach based on the clinical trial carried out in a hospital setting. Thus, the foundation for improving the current approach toward preventing CINV in cancer patients undergoing chemotherapy will be built.

Research Question (PICOT)


Hispanic patients diagnosed with gastric cancer, currently undergoing chemotherapy (FOLFOX), and suffering from CINV symptoms are the target population of the research.


An observation of the effects produced by two different types of CINV management strategies (i.e., the pharmacological and alternative ones) will be carried out in the course of the research. The patients will be provided with both traditional (antiemetics-based, e.g., involving the use of Palonosetron) alternative (herbal) medicine as the means of reducing the CINV symptoms and addressing the subject matter (Vidall, Sharma, & Amlani, 2016).


The efficacy of Palonosetron will be compared to the one of herbal medicine provided to the target population. Presumably, the use of herbal treatment as the means of reducing nausea and vomiting will allow developing an individual approach toward the needs of each patient and, thus, manage the problem more successfully (Navari, 2013).


It is expected that the strategies for reducing the levels of CINV will be developed after the research is over. Particularly, the selection of an appropriate method of preventing the development of CINV symptoms will be carried out.


The study will take presumably around three months to implement the treatment strategies, observe their effects, gather the necessary information, and analyze it accordingly. Therefore, the results will be presented within three months from the start of the study.

PICOT Question

(P) In Hispanic gastric cancer patients, (I) will the use of Chinese herbal medicine such as Shenqi fuzheng (C) prove to be more efficient than antiemetic treatment, i.e., the use of Olanzapine, in (O) preventing and addressing CINV (T) within three months?

The use of Chinese herbal medicine will serve as the intervention strategy, whereas the patients provided with Olanzapine as antiemetic treatment will represent the comparison group. Both prevention and management of CINV will be considered in the study. Despite a comparatively tight deadline, it is expected that there will be enough patients to carry out the research. In the USC Norris Cancer Center, which will serve as the study setting, FOLFOX (5-FU, Leucovorin, and Oxaliplatin) is administered to 12 patients with metastatic gastric cancer. Chemotherapy infusion is given every two weeks, and most of the patients recover within 6-12 months. The youngest patient, a 26-year-old woman, is on cycle 43 now. It is expected that the research results will help address the CINV issue successfully.


Janelsins, M. C., Tejani, M., Kamen, C., Peoples, A., Mustian, K. M., & Morrow, G. R. (2013). Current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients. Expert Opinion on Pharmacotherapy, 14(6), 757-766. Web.

Jiang, L., Wang, J. C., Ma, B., Gao, W., Chen, P., Sun, R. & Yang, K. H, (2015). Shenqi fuzheng injection for advanced gastric cancer: A systematic review of randomized controlled trials. Chinese Journal of Integrative Medicine, 21(1), 71-79. Web.

National Cancer Institute. (2014). Web.

National Cancer Institute. (2016). Web.

Navari, R. M. (2013). Management of chemotherapy-induced nausea and vomiting. Drugs, 73(3), 249-262. Web.

Sheikhi, M. A., Ebadi, A., Talaeizadeh, A., & Rahmani, H. (2015). Alternative methods to treat nausea and vomiting from cancer chemotherapy. Chemotherapy Research and Practice, 2015(818759), 1-6. Web.

Vidall, C., Sharma, S., & Amlani, B. (2016). Patient–practitioner perception gap in treatment-induced nausea and vomiting. British Journal of Nursing, 25(16), 4-11. Web.

Calculate the price
Make an order in advance and get the best price
Pages (550 words)
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
How it works
Receive a 100% original paper that will pass Turnitin from a top essay writing service
step 1
Upload your instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
Pro service tips
How to get the most out of your experience with Online Academic Experts
One writer throughout the entire course
If you like the writer, you can hire them again. Just copy & paste their ID on the order form ("Preferred Writer's ID" field). This way, your vocabulary will be uniform, and the writer will be aware of your needs.
The same paper from different writers
You can order essay or any other work from two different writers to choose the best one or give another version to a friend. This can be done through the add-on "Same paper from another writer."
Copy of sources used by the writer
Our college essay writers work with ScienceDirect and other databases. They can send you articles or materials used in PDF or through screenshots. Just tick the "Copy of sources" field on the order form.
See why 20k+ students have chosen us as their sole writing assistance provider
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
thank you so much
Customer 452749, June 10th, 2021
Social Work and Human Services
Although it took 2 revisions I am satisfied but I did receive it late because of that.
Customer 452603, March 25th, 2021
Emergency Management
Overall, I think it's a great service. I have yet to submit the assignment, so I don't know what kind of grade I'll get. But customer service was excellent. Reviews were made and the assignment proofed for satisfaction.
Customer 453015, December 15th, 2021
Business Management
Awesome job, Thank you
Customer 453201, June 12th, 2022
Nice work
Customer 453185, May 21st, 2022
Business Studies
Paper is great. Just only needed the one reference. Thank you
Customer 453139, May 4th, 2022
It was gotten well after time I needed to make needed additions, but it is something that did help me. I could not get the concept of ho to start such a project but now reading this, I was over thinking the project it seems.
Customer 452801, July 19th, 2021
Business and administrative studies
awesome job
Customer 453201, June 24th, 2022
Thank you!!! I received my order in record timing.
Customer 452551, February 9th, 2021
Criminal Justice
This has been the greatest help while I am recovering from an illness. Thank your team so much.
Customer 452671, May 2nd, 2021
Business Studies
Customer 452985, November 11th, 2021
English 101
very good paper thank you.
Customer 453083, February 18th, 2022
Customer reviews in total
Current satisfaction rate
3 pages
Average paper length
Customers referred by a friend
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat
Live ChatWhatsApp